The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans.

doi:10.1016/j.cub.2005.05.057

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Article

The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans.

Current biology : CB - 12 Jul 2005

Syntichaki Popi, Samara Chrysanthi, Tavernarakis Nektarios

Abstract excerpt

Numerous studies implicate necrotic cell death in devastating human pathologies such as stroke and neurodegenerative diseases. Investigations in both nematodes and mammals converge to implicate specific calpain and aspartyl proteases in the execution of necrotic cell death. It is believed that these proteases become activated under conditions that inflict necrotic cell death. However, the factors that modulate...

Topics

Animals
Aspartic Acid Endopeptidases
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Computational Biology
Cytoplasm
DNA Primers
Hydrogen-Ion Concentration
Necrosis
Neurons
Phenotype
Plasmids
RNA Interference
Vacuolar Proton-Translocating ATPases

Source

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Identifiers

PMID: 16005300
DOI: 10.1016/j.cub.2005.05.057

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