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Article

The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans.

Current biology : CB - 12 Jul 2005

Syntichaki Popi, Samara Chrysanthi, Tavernarakis Nektarios

Abstract excerpt

Numerous studies implicate necrotic cell death in devastating human pathologies such as stroke and neurodegenerative diseases. Investigations in both nematodes and mammals converge to implicate specific calpain and aspartyl proteases in the execution of necrotic cell death. It is believed that these proteases become activated under conditions that inflict necrotic cell death. However, the factors that modulate...

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Identifiers

PMID: 16005300
DOI: 10.1016/j.cub.2005.05.057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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