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Article

An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury.

Cell - 21 Sept 2007

Luke Cliff J, Pak Stephen C, Askew Yuko S, Naviglia Terra L, Askew David J, Nobar Shila M, Vetica Anne C, Long Olivia S, Watkins Simon C, Stolz Donna B, Barstead Robert J, Moulder Gary L, Brömme Dieter, Silverman Gary A

Abstract excerpt

Extracellular serpins such as antithrombin and alpha1-antitrypsin are the quintessential regulators of proteolytic pathways. In contrast, the biological functions of the intracellular serpins remain obscure. We now report that the C. elegans intracellular serpin, SRP-6, exhibits a prosurvival function by blocking necrosis. Minutes after hypotonic shock, srp-6 null animals underwent a catastrophic series of events...

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Identifiers

PMID: 17889653
DOI: 10.1016/j.cell.2007.07.013
PMCID: PMC2128786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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