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Article

Neuropathology of degenerative cell death in Caenorhabditis elegans.

1 Feb 1997

Abstract excerpt

In Caenorhabditis elegans necrosis-like neuronal death is induced by gain-of-function (gf) mutations in two genes, mec-4 and deg-1, that encode proteins similar to subunits of the vertebrate amiloride-sensitive epithelial Na+ channel. We have determined the progress of cellular pathology in dying neurons via light and electron microscopy. The first detectable abnormality is an infolding of the plasma membrane and...

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PMID: 8994058
DOI: 10.1523/jneurosci.17-03-01033.1997

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