Article
PKG and NHR-49 signalling co-ordinately regulate short-term fasting-induced lysosomal lipid accumulation in C. elegans.
The Biochemical journal - 1 Aug 2014
Huang Wen-ming, Li Zhao-yu, Xu Yan-jun, Wang Wei, Zhou Mao-ge, Zhang Peng, Liu Ping-sheng, Xu Tao, Wu Zheng-xing
Abstract excerpt
Lysosomes act as terminal degradation organelles to hydrolyse macromolecules derived from both the extracellular space and the cytoplasm. In Caenorhabditis elegans fasting induces the lysosomal compartment to expand. However, the molecular and cellular mechanisms for this stress response remain largely unclear. In the present study, we find that short-term fasting leads to increased accumulation of polar lipids...
Topics
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cyclic GMP-Dependent Protein Kinases
- Enzyme Activation
- Fasting
- Hydrolases
- Kinetics
- Lipid Metabolism
- Lysosomes
- Mutation
- Nerve Tissue Proteins