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Article

Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans.

Nature - 31 Oct 2002

Syntichaki Popi, Xu Keli, Driscoll Monica, Tavernarakis Nektarios

Abstract excerpt

Necrotic cell death underlies the pathology of numerous human neurodegenerative conditions. In the nematode Caenorhabditis elegans, gain-of-function mutations in specific ion channel genes such as the degenerin genes deg-1 and mec-4, the acetylcholine receptor channel subunit gene deg-3 and the G(s) protein alpha-subunit gene gsa-1 evoke an analogous pattern of degenerative (necrotic-like) cell death in neurons...

Topics

Animals
Aspartic Acid Endopeptidases
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Calcium
Calpain
Cell Death
Cell Survival
Genes, Reporter
Membrane Proteins
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Necrosis

Neurodegenerative Diseases

Neurons

RNA Interference

Sodium Channels

Source

Identifiers

PMID: 12410314
DOI: 10.1038/nature01108

Genes

TRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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