Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans.

Nature - 31 Oct 2002

Syntichaki Popi, Xu Keli, Driscoll Monica, Tavernarakis Nektarios

Abstract excerpt

Necrotic cell death underlies the pathology of numerous human neurodegenerative conditions. In the nematode Caenorhabditis elegans, gain-of-function mutations in specific ion channel genes such as the degenerin genes deg-1 and mec-4, the acetylcholine receptor channel subunit gene deg-3 and the G(s) protein alpha-subunit gene gsa-1 evoke an analogous pattern of degenerative (necrotic-like) cell death in neurons...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid Endopeptidases
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Calpain

Share to Cell Death

Share to Genes, Reporter

Share to Necrosis

Share to Neurodegenerative Diseases

Share to Sodium Channels

Source

Identifiers

PMID: 12410314
DOI: 10.1038/nature01108

Genes

TRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans.PMID 12410314Read ↗

Molecular genetics of cell death in the nematode Caenorhabditis elegans.Semantic proximity Read ↗

Neuropathology of degenerative cell death in Caenorhabditis elegans.Semantic proximity Read ↗

TDP-43 Toxicity Proceeds via Calcium Dysregulation and Necrosis in Aging<i>Caenorhabditis elegans</i>Motor NeuronsSemantic proximity Read ↗

The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans.Semantic proximity Read ↗

Identification of presenilin mutations that have sufficient gamma-secretase proteolytic activity to mediate Notch signaling but disrupt organelle and neuronal healthSemantic proximity Read ↗

Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain.Semantic proximity Read ↗

Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans.Semantic proximity Read ↗

Programmed cell deathSemantic proximity Read ↗

A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans.Semantic proximity Read ↗

Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum.Semantic proximity Read ↗

An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury.Semantic proximity Read ↗

Mechanisms of neuronal death in disease: defining the models and the playersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.