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Article

Alpha1-antitrypsin and neutrophil elastase imbalance and lung cancer risk.

Chest - 1 Jul 2005

Yang Ping, Bamlet William R, Sun Zhifu, Ebbert Jon O, Aubry Marie-Christine, Krowka Michael J, Taylor William R, Marks Randolph S, Deschamps Claude, Swensen Stephen J, Wieben Eric D, Cunningham Julie M, Melton Lee Joseph, de Andrade Mariza

Abstract excerpt

OBJECTIVE: Imbalance between alpha(1)-antitrypsin and neutrophil elastase is an underlying cause of lung tissue damage that may create a favorable host environment for carcinogenesis. We conducted a case-control study to investigate whether genetic variations indicative of alpha(1)-antitrypsin deficiency (A1ATD) or an excess of neutrophil elastase modify lung cancer risk DESIGN: The case patients were 305...

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PMID: 16002971
DOI: 10.1378/chest.128.1.445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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