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Article

Alpha-1-antitrypsin phenotypes and neutrophil elastase gene promoter polymorphisms in lung cancer.

Pathology oncology research : POR - 1 Mar 2011

Topic Aleksandra, Ljujic Mila, Nikolic Aleksandra, Petrovic-Stanojevic Natasa, Dopudja-Pantic Vesna, Mitic-Milikic Marija, Radojkovic Dragica

Abstract excerpt

Imbalance between neutrophil elastase and alpha-1-antitrypsin (AAT) leads to emphysema in smokers as well as in patients with inherited alpha-1-antitrypsin deficiency. AAT as a proven inhibitor of apoptosis may play role in lung cancer (LC) progression. The aim was to analyse AAT protein variants and polymorphism in promoter region of the neutrophil elastase gene (ELA2) in patients with primary lung cancer. AAT...

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Share to alpha 1-Antitrypsin
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukocyte Elastase

Share to Lung Neoplasms

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Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Share to Small Cell Lung Carcinoma

Source

Identifiers

PMID: 20521180
DOI: 10.1007/s12253-010-9283-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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