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Article

Metalloproteases/anti-metalloproteases imbalance in chronic obstructive pulmonary disease: genetic factors and treatment implications.

Current opinion in pulmonary medicine - 1 Dec 2011

Mocchegiani Eugenio, Giacconi Robertina, Costarelli Laura

Abstract excerpt

PURPOSE OF REVIEW: The aim is to describe the involvement of matrix metalloprotease (MMP), A Disintegrin And Metalloproteases (ADAM), tissue inhibitors of MMP (TIMP) polymorphisms and the role of α-2 Macroglobulin (α-2M) in chronic obstructive pulmonary disease (COPD) development and progression, with a focus on interventions with synthetic MMP inhibitors alone or associated with current drugs used in COPD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22209925
DOI: 10.1097/01.mcp.0000410743.98087.12

Genes

ADAM33
MMP1
MMP12
MMP2
MMP9
TIMP1
TIMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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