Article
[Alpha 1-antiproteinase deficiency].
Therapeutische Umschau. Revue therapeutique - 1 Mar 1999
Ritscher D, Russi E W
Abstract excerpt
The dysbalance between proteolytic neutrophil elastase and its endogeneous inhibitor seems to be a pathogenetic key mechanism in the origin of pulmonary emphysema (elastase-antielastase hypothesis). This hypothesis is supported by the observation, that low serum levels of alpha 1-antitrypsin can be observed in smokers with premature pulmonary emphysema. alpha 1-proteinase inhibitor is an acute phase protein with...
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