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Article

Polymorphisms in the promoter region of the neutrophil elastase gene are associated with lung cancer development.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2002

Taniguchi Ken, Yang Ping, Jett James, Bass Eric, Meyer Rebecca, Wang Yunjie, Deschamps Claude, Liu Wanguo

Abstract excerpt

Neutrophil elastase (NE) is a powerful serine protease capable of degrading most protein components of the extracellular matrix. We hypothesize that this elastase may play a significant role in lung cancer development and tested our hypothesis in a study of 348 primary lung cancer cases and 299 controls. Analysis of the entire gene using denaturing high performance liquid chromatography identified two novel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 11948122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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