Article
Alpha1-antitrypsin deficiency allele carriers among lung cancer patients.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 1999
Yang P, Wentzlaff K A, Katzmann J A, Marks R S, Allen M S, Lesnick T G, Lindor N M, Myers J L, Wiegert E, Midthun D E, Thibodeau S N, Krowka M J
Abstract excerpt
Lung cancer (LC) and chronic obstructive pulmonary lung diseases (COPDs; including emphysema and chronic bronchitis) share a common etiology. Despite the known associations of alpha1-antitrypsin deficiency (alpha1AD) with COPD and COPD with LC, few studies examined the association of alpha1AD alleles and LC. We hypothesize that heterozygous individuals who carry a deficient allele of the alpha1AD gene Pi...
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