Article
SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer.
Anticancer research - 1 Sept 2012
Enewold Lindsey, Mechanic Leah E, Bowman Elise D, Platz Elizabeth A, Alberg Anthony J
Abstract excerpt
BACKGROUND: Through their roles in tissue remodeling, variants in the genes that encode alpha1-antitrypsin (AAT) and neutrophil elastase (NE) were hypothesized to be associated with the risk of both chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Cases with prevalent COPD (n=145), incident NSCLC (n=203) or prevalent COPD plus NSCLC (n=118) were compared...
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