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Article

ALPHA-1 antitrypsin genotype, sex, and lung cancer: Clinical and molecular characterisation.

Pulmonology - 1 Dec 2026

García-Rodríguez Esmeralda, Tubío-Pérez Ramón Antonio, Candal-Pereira Cristina, Villar-Aguilar Laura, Priegue-Carrera Ana, Fernández-Villar Alberto, Ruano-Raviña Alberto, Torres-Durán María

Abstract excerpt

INTRODUCTION AND OBJECTIVES: Alpha-1 antitrypsin deficiency is associated with lung and liver disease, but its role in lung carcinogenesis remains unclear. This study aimed to compare the clinical, functional, and molecular characteristics of lung cancer according to alpha-1 antitrypsin (AAT) genotype and, additionally, to explore differences by sex and the possible influence of environmental exposures. PATIENTS...

Read the complete abstract on PubMed

Topics

Humans
Female
Lung Neoplasms
alpha 1-Antitrypsin
Male
Cross-Sectional Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genotype

Middle Aged

alpha 1-Antitrypsin Deficiency

Aged

Sex Factors

Alleles

Source

Identifiers

PMID: 42750455
DOI: 10.1080/25310429.2026.2735063

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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