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Article

Stable transmission of targeted gene modification using single-stranded oligonucleotides with flanking LNAs.

Nucleic acids research - 1 Jan 2005

Andrieu-Soler Charlotte, Casas Mariana, Faussat Anne-Marie, Gandolphe Christelle, Doat Marc, Tempé Denis, Giovannangeli Carine, Behar-Cohen Francine, Concordet Jean-Paul

Abstract excerpt

Targeted mutagenesis directed by oligonucleotides (ONs) is a promising method for manipulating the genome in higher eukaryotes. In this study, we have compared gene editing by different ONs on two new target sequences, the eBFP and the rd1 mutant photoreceptor betaPDE cDNAs, which were integrated as single copy transgenes at the same genomic site in 293T cells. Interestingly, antisense ONs were superior to sense...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclic Nucleotide Phosphodiesterases, Type 6

Share to DNA, Single-Stranded

Share to Luminescent Proteins

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Share to Oligonucleotides, Antisense

Share to Photoreceptor Cells, Vertebrate

Source

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Identifiers

PMID: 16002788
DOI: 10.1093/nar/gki686
PMCID: PMC1174897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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