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Article

A non-glycosaminoglycan-binding variant of CC chemokine ligand 7 (monocyte chemoattractant protein-3) antagonizes chemokine-mediated inflammation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2005

Ali Simi, Robertson Helen, Wain Julie H, Isaacs John D, Malik Ghada, Kirby John A

Abstract excerpt

A non-glycosaminoglycan (GAG)-binding variant of the pleiotropic chemokine CCL7 was generated by mutating to alanine the basic (B) amino acids within an identified (44)BXBXXB(49) GAG-binding motif. Unlike wild-type (wt) CCL7, the mutant sequence had no affinity for heparin. However, the mutant retained a normal affinity for CCR1, CCR2b, and CCR3, and produced a normal calcium flux in mononuclear leukocytes. Both...

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Topics

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Share to Chemokines
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelium, Vascular

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Source

Identifiers

PMID: 16002730
DOI: 10.4049/jimmunol.175.2.1257

Genes

CCL7
CCL5
CCR1
CCR3
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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