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Article

Multiple glycosaminoglycan-binding epitopes of monocyte chemoattractant protein-3/CCL7 enable it to function as a non-oligomerizing chemokine.

The Journal of biological chemistry - 23 May 2014

Salanga Catherina L, Dyer Douglas P, Kiselar Janna G, Gupta Sayan, Chance Mark R, Handel Tracy M

Abstract excerpt

The interaction of chemokines with glycosaminoglycans (GAGs) facilitates the formation of localized chemokine gradients that provide directional signals for migrating cells. In this study, we set out to understand the structural basis and impact of the differing oligomerization propensities of the chemokines monocyte chemoattractant protein (MCP)-1/CCL2 and MCP-3/CCL7 on their ability to bind GAGs. These...

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Share to Chemokine CCL2
Share to Electrophoresis, Polyacrylamide Gel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes

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Share to Mass Spectrometry

Share to Protein Multimerization

Share to Sequence Homology, Amino Acid

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Source

Open in PubMed Open full text

Identifiers

PMID: 24727473
DOI: 10.1074/jbc.M114.547737
PMCID: PMC4031540

Genes

CCL2
CCL7
SPR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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