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Article

Interference with heparin binding and oligomerization creates a novel anti-inflammatory strategy targeting the chemokine system.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2004

Johnson Zoë, Kosco-Vilbois Marie H, Herren Suzanne, Cirillo Rocco, Muzio Valeria, Zaratin Paola, Carbonatto Michela, Mack Matthias, Smailbegovic Amir, Rose Mark, Lever Rebecca, Page Clive, Wells Timothy N C, Proudfoot Amanda E I

Abstract excerpt

A hallmark of autoimmunity and other chronic diseases is the overexpression of chemokines resulting in a detrimental local accumulation of proinflammatory immune cells. Chemokines play a pivotal role in cellular recruitment through interactions with both cell surface receptors and glycosaminoglyc...

Read the complete abstract on PubMed

Topics

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Share to Anti-Inflammatory Agents, Non-Steroidal
Share to Bronchoalveolar Lavage Fluid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokine CCL5

Share to Desensitization, Immunologic

Share to Heparin

Share to Inflammation Mediators

Share to Microscopy, Video

Share to Peritoneum

Source

Identifiers

PMID: 15494530
DOI: 10.4049/jimmunol.173.9.5776

Genes

CCL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15494530-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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