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Article

Kinetics of chemokine-glycosaminoglycan interactions control neutrophil migration into the airspaces of the lungs.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2010

Tanino Yoshi, Coombe Deirdre R, Gill Sean E, Kett Warren C, Kajikawa Osamu, Proudfoot Amanda E I, Wells Timothy N C, Parks William C, Wight Thomas N, Martin Thomas R, Frevert Charles W

Abstract excerpt

Chemokine-glycosaminoglycan (GAG) interactions are thought to result in the formation of tissue-bound chemokine gradients. We hypothesized that the binding of chemokines to GAGs would increase neutrophil migration toward CXC chemokines instilled into lungs of mice. To test this hypothesis we compared neutrophil migration toward recombinant human CXCL8 (rhCXCL8) and two mutant forms of CXCL8, which do not bind to...

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Identifiers

PMID: 20124102
DOI: 10.4049/jimmunol.0903274
PMCID: PMC4113427

Genes

CXCL8
MIP

Provenance

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