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Article

Identification of CC chemokine receptor 7 residues important for receptor activation.

The Journal of biological chemistry - 8 Oct 2004

Ott Thomas R, Pahuja Anil, Nickolls Sarah A, Alleva David G, Struthers R Scott

Abstract excerpt

The binding pocket of family A GPCRs that bind small biogenic amines is well characterized. In this study we identify residues on CC chemokine receptor 7 (CCR-7) that are involved in agonist-mediated receptor activation but not in high affinity ligand binding. The mutations also affect the ability of the ligands to induce chemotaxis. Two of the residues, Lys3.33(137) and Gln5.42(227), are consistent with the...

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Identifiers

PMID: 15284247
DOI: 10.1074/jbc.M401097200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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