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Identification of conserved T cell epitopes and flanking amino acid mutants of endogenous retrovirus Gag antigen in nonobese diabetic mice.

ImmunoHorizons - 25 Aug 2025

Dai Yang D, Li Shuhui, Margosiak Amanda, Hu Wen-Yuan

Abstract excerpt

The interactions between endogenous retroviruses (ERVs) and major histocompatibility complex molecules may significantly influence autoimmune diseases due to their common roles in the evolution and development of the adaptive immune system. Notably, regions within the Gag antigens of a specific group of ERVs, similar to murine leukemia retroviruses, exhibit patterns of sequence conservation, variation, and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40854595
DOI: 10.1093/immhor/vlaf033
PMCID: PMC12377906

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