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Article

Tertiary lymphoid structures in the pancreas promote selection of B lymphocytes in autoimmune diabetes.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2007

Kendall Peggy L, Yu Guowu, Woodward Emily J, Thomas James W

Abstract excerpt

Autoimmune diabetes occurs when invading lymphocytes destroy insulin-producing beta cells in pancreatic islets. The role of lymphocytic aggregates at this inflammatory site is not understood. We find that B and T lymphocytes attacking islets in NOD mice organize into lymphoid structures with germinal centers. Analysis of BCR L chain genes was used to investigate selection of B lymphocytes in these tertiary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17442947
DOI: 10.4049/jimmunol.178.9.5643

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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