Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic bases of Progressive Supranuclear Palsy: the MAPT tau disease.

Current medicinal chemistry - 1 Jan 2011

Borroni Barbara, Agosti Chiara, Magnani Enrico, Di Luca Monica, Padovani Alessandro

Abstract excerpt

Progressive Supranuclear Palsy (PSP) is a progressive neurodegenerative syndrome characterized by supranuclear palsy, postural instability, and mild dementia. Neuropathologically, PSP is a four-repeat tauopathy, defined by the accumulation of neurofibrillary tangles and tufted astrocytes. Etiology remains elusive, but genetic background has a key-role in the disease pathogenesis. Recent studies have reported high...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Genome-Wide Association Study
Share to Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neurofibrillary Tangles

Share to Supranuclear Palsy, Progressive

Share to tau Proteins

Share to Tauopathies

Source

Identifiers

PMID: 21568901
DOI: 10.2174/092986711795933722

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic bases of Progressive Supranuclear Palsy: the MAPT tau disease.PMID 21568901Read ↗

Genetics of Progressive Supranuclear PalsySemantic proximity Read ↗

Genetics of Progressive Supranuclear Palsy: A ReviewSemantic proximity Read ↗

Genetic and Epigenetic Constructs of Progressive Supranuclear PalsySemantic proximity Read ↗

Genetic variation at the tau locus and clinical syndromes associated with progressive supranuclear palsy.Semantic proximity Read ↗

Novel Therapeutic Targets and Biomarkers for the Treatment of Progressive Supranuclear PalsySemantic proximity Read ↗

Familial aggregation of parkinsonism in progressive supranuclear palsy.Semantic proximity Read ↗

The H1c haplotype at the MAPT locus is associated with Alzheimer's disease.Semantic proximity Read ↗

The structure of the tau haplotype in controls and in progressive supranuclear palsy.Semantic proximity Read ↗

Disentangling the role of the tau gene locus in sporadic tauopathies.Semantic proximity Read ↗

Motor and non-motor features in progressive supranuclear palsy: the impact of microtubule associated protein tau haplotypes among a Tunisian cohort.Semantic proximity Read ↗

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.Semantic proximity Read ↗

Untangling the tau gene association with neurodegenerative disordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.