Article
The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts.
Neurobiology of disease - 1 Mar 2007
Myers Amanda J, Pittman Alan M, Zhao Alice S, Rohrer Kristen, Kaleem Mona, Marlowe Lauren, Lees Andrew, Leung Doris, McKeith Ian G, Perry Robert H, Morris Chris M, Trojanowski John Q, Clark Christopher, Karlawish Jason, Arnold Steve, Forman Mark S, Van Deerlin Vivianna, de Silva Rohan, Hardy John
Abstract excerpt
Previously we have shown that the H1c haplotype on the background of the H1 clade of haplotypes at the MAPT locus is associated with increased risk for progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and Alzheimer's disease (AD). Here we replicated the association with AD in an additional autopsy confirmed series. We show that this haplotype increases both the expression of total MAPT...
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