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Article

Novel haplotypes in 17q21 are associated with progressive supranuclear palsy.

Annals of neurology - 1 Aug 2004

Pastor Pau, Ezquerra Mario, Perez J Christian, Chakraverty Sumi, Norton Joanne, Racette Brad A, McKeel Dan, Perlmutter Joel S, Tolosa Eduardo, Goate Alison M

Abstract excerpt

Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are sporadic neurodegenerative diseases presenting as atypical parkinsonian disorders, characterized by the presence of tau-positive neurofibrillary tangles. Recently, an extended haplotype (H1E) of 787.6 kb that comprises several genes including MAPT showed increased association with PSP. The objective of this study was to determine the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15293277
DOI: 10.1002/ana.20178

Genes

MAPT
CRHR1
NSF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel haplotypes in 17q21 are associated with progressive supranuclear palsy.PMID 15293277Read ↗

Different MAPT haplotypes are associated with Parkinson's disease and progressive supranuclear palsy.Semantic proximity Read ↗

Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype.Semantic proximity Read ↗

Target-enriched sequencing of chromosome 17q21.31 in sporadic tauopathies reveals no candidate variants.Semantic proximity Read ↗

The structure of the tau haplotype in controls and in progressive supranuclear palsy.Semantic proximity Read ↗

Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration.Semantic proximity Read ↗

An extended 5'-tau susceptibility haplotype in progressive supranuclear palsy.Semantic proximity Read ↗

The H1c haplotype at the MAPT locus is associated with Alzheimer's disease.Semantic proximity Read ↗

Further extension of the H1 haplotype associated with progressive supranuclear palsy.Semantic proximity Read ↗

5'-Upstream variants of CRHR1 and MAPT genes associated with age at onset in progressive supranuclear palsy and cortical basal degeneration.Semantic proximity Read ↗

Motor and non-motor features in progressive supranuclear palsy: the impact of microtubule associated protein tau haplotypes among a Tunisian cohort.Semantic proximity Read ↗

Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear PalsySemantic proximity Read ↗

Genetic bases of Progressive Supranuclear Palsy: the MAPT tau disease.Semantic proximity Read ↗

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