Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effect of age and the H1c MAPT haplotype on MAPT expression in human brain.

Neurobiology of aging - 1 Oct 2009

Hayesmoore Jesse B G, Bray Nicholas J, Cross William C, Owen Michael J, O'Donovan Michael C, Morris Huw R

Abstract excerpt

The MAPT H1c haplotype is a risk factor for the neurodegenerative tauopathies progressive supranuclear palsy (PSP) and Alzheimer's disease. We hypothesise that the effect of the H1c haplotype relates to an increase in MAPT expression leading to an increase in tau neurofibrillary tangle deposition. We have evaluated the effect of the MAPT H1c haplotype on the expression of MAPT using allele specific expression,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Aging
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Haplotypes

Share to Longevity

Share to RNA, Messenger

Share to tau Proteins

Source

Identifiers

PMID: 18276036
DOI: 10.1016/j.neurobiolaging.2007.12.017

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effect of age and the H1c MAPT haplotype on MAPT expression in human brain.PMID 18276036Read ↗

Haplotype-specific expression of exon 10 at the human MAPT locus.Semantic proximity Read ↗

The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts.Semantic proximity Read ↗

The H1c haplotype at the MAPT locus is associated with Alzheimer's disease.Semantic proximity Read ↗

The Role of MAPT Haplotype H2 and Isoform 1N/4R in Parkinsonism of Older Adults.Semantic proximity Read ↗

MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies.Semantic proximity Read ↗

Tau haplotypes regulate transcription and are associated with Parkinson's disease.Semantic proximity Read ↗

Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration.Semantic proximity Read ↗

Different MAPT haplotypes are associated with Parkinson's disease and progressive supranuclear palsy.Semantic proximity Read ↗

The role of MAPT sequence variation in mechanisms of disease susceptibility.Semantic proximity Read ↗

Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue.Semantic proximity Read ↗

The MAPT H1 haplotype is associated with tangle-predominant dementia.Semantic proximity Read ↗

Genetic Architecture of MAPT Gene Region in Parkinson Disease SubtypesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.