B cell development and its deregulation to transformed states at the pre-B cell receptor-expressing pre-BII cell stage.

doi:10.1007/3-540-29933-5_1

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B cell development and its deregulation to transformed states at the pre-B cell receptor-expressing pre-BII cell stage.

Current topics in microbiology and immunology - 1 Jan 2005

Melchers F

Abstract excerpt

This chapter will review the scenario of normal B cell development--from the decision of a lymphoid progenitor to enter the B-lineage, over the stages of the generation of the repertoires of antigen-receptor (immunoglobulin)-expressing cells, to the response of mature B cells to develop memory and plasma cells--highlighting some of the cellular stages and the molecular mechanisms that can generate and select...

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B cell development and its deregulation to transformed states at the pre-B cell receptor-expressing pre-BII cell stage.

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