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Article

Censoring of Autoreactive B Cell Development by the Pre-B Cell Receptor

19 Jun 2008

Abstract excerpt

Antibody diversity occurs randomly as B cells recombine their immunoglobulin (Ig) heavy- and light-chain genes during development. This process inevitably generates reactivity against self structures, and several mechanisms prevent the development of autoreactive B cells. We report here a role for the pre-B cell receptor, composed of Ig heavy and surrogate light chains, in the negative selection of cells...

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PMID: 18566249
DOI: 10.1126/science.1157533

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