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Article

Prepulse inhibition and genetic mouse models of schizophrenia.

Behavioural brain research - 7 Dec 2009

Powell Susan B, Zhou Xianjin, Geyer Mark A

Abstract excerpt

Mutant mouse models related to schizophrenia have been based primarily on the pathophysiology of schizophrenia, the known effects of antipsychotic drugs, and candidate genes for schizophrenia. Sensorimotor gating deficits in schizophrenia patients, as indexed by measures of prepulse inhibition of startle (PPI), have been well characterized and suggested to meet the criteria as a useful endophenotype in human...

Topics

Animals
Brain
Disease Models, Animal
Environment
Genetic Predisposition to Disease
Glutamic Acid
Glycine
Mice
Mice, Transgenic
Nerve Net
Phenotype
Schizophrenia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sensory Gating

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Identifiers

PMID: 19397931
DOI: 10.1016/j.bbr.2009.04.021
PMCID: PMC2735602

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