Article
Unconventional homologous internalization of the angiotensin II type-1 receptor induced by G-protein-independent signals.
Hypertension (Dallas, Tex. : 1979) - 1 Aug 2005
Feng Ying-Hong, Ding Yaxian, Ren Shuo, Zhou Lingyin, Xu Chuan, Karnik Sadashiva S
Abstract excerpt
Internalization of a G-protein-coupled receptor (GPCR) is essential to the desensitization, endocytosis, and signal transduction of the receptor. It has been the general view that conventional homologous internalization of a GPCR requires activation of the G-protein(s) coupled to the receptor. However, whether and how GPCR-mediated G-protein-independent signals trigger receptor internalization remains unknown,...
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