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Article

Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors.

Biochemistry - 8 Oct 2002

Wilbanks Alyson M, Laporte Stéphane A, Bohn Laura M, Barak Larry S, Caron Marc G

Abstract excerpt

The DRY motif is a triplet amino acid sequence (aspartic acid, arginine, and tyrosine) that is highly conserved in G protein-coupled receptors (GPCRs). Recently, we have shown that a molecular determinant for nephrogenic diabetes insipidus, the vasopressin receptor with a substitution at the DRY motif arginine (V2R R137H), is a constitutively desensitized receptor that is unable to couple to G proteins due to its...

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PMID: 12356298
DOI: 10.1021/bi020275m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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