Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endoplasmic reticulum export of adrenergic and angiotensin II receptors is differentially regulated by Sar1 GTPase.

Cellular signalling - 1 Jun 2008

Dong Chunmin, Zhou Fuguo, Fugetta Erin K, Filipeanu Catalin M, Wu Guangyu

Abstract excerpt

The molecular mechanism underlying the export of G protein-coupled receptors (GPCRs) from the endoplasmic reticulum (ER) remains largely unknown. In this manuscript, we investigated the role of Sar1 GTPase, which coordinates the assembly and budding of COPII-coated vesicles, in the cell-surface targeting, signaling and ER export of alpha(2B)-adrenergic (alpha(2B)-AR), beta(2)-AR and angiotensin II type 1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Membrane
Share to Endoplasmic Reticulum

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Monomeric GTP-Binding Proteins

Share to Protein Transport

Share to Receptor, Angiotensin, Type 1

Share to Receptors, Adrenergic

Share to Receptors, Adrenergic, alpha-2

Share to Receptors, Adrenergic, beta-2

Source

Open in PubMed Open full text

Identifiers

PMID: 18378118
DOI: 10.1016/j.cellsig.2008.01.014
PMCID: PMC2413292

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endoplasmic reticulum export of adrenergic and angiotensin II receptors is differentially regulated by Sar1 GTPase.PMID 18378118Read ↗

Rab8 interacts with distinct motifs in alpha2B- and beta2-adrenergic receptors and differentially modulates their transport.Semantic proximity Read ↗

A conserved motif for the transport of G protein-coupled receptors from the endoplasmic reticulum to the cell surface.Semantic proximity Read ↗

Receptor/beta-arrestin complex formation and the differential trafficking and resensitization of beta2-adrenergic and angiotensin II type 1A receptors.Semantic proximity Read ↗

COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis.Semantic proximity Read ↗

Mechanisms and functions of AT(1) angiotensin receptor internalization.Semantic proximity Read ↗

Differential effects of a GTP-restricted mutant of Sar1p on segregation of cargo during export from the endoplasmic reticulum.Semantic proximity Read ↗

The intracellular transport of chylomicrons requires the small GTPase, Sar1b.Semantic proximity Read ↗

Regulation of angiotensin II type 1A receptor intracellular retention, degradation, and recycling by Rab5, Rab7, and Rab11 GTPases.Semantic proximity Read ↗

Regulation of β2-adrenergic receptor maturation and anterograde trafficking by an interaction with Rab geranylgeranyltransferase: modulation of Rab geranylgeranylation by the receptor.Semantic proximity Read ↗

Rab1 GTPase regulates phenotypic modulation of pulmonary artery smooth muscle cells by mediating the transport of angiotensin II type 1 receptor under hypoxia.Semantic proximity Read ↗

A single lys residue on the first intracellular loop modulates the endoplasmic reticulum export and cell-surface expression of α2A-adrenergic receptor.Semantic proximity Read ↗

The angiotensin II type 1 receptor C-terminal Lys residues interact with tubulin and modulate receptor export trafficking.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.