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Article

AT1 receptor blocker-insensitive mutant AT1A angiotensin receptors reveal the presence of G protein-independent signaling in C9 cells.

Biochemical pharmacology - 15 May 2007

Szidonya László, Süpeki Katinka, Karip Eszter, Turu Gábor, Várnai Péter, Clark Adrian J L, Hunyady László

Abstract excerpt

Although mutant receptors are highly useful to dissect the signal transduction pathways of receptors, they are difficult to study in physiological target tissues, due to the presence of endogenous receptors. To study AT(1) angiotensin receptors in their physiological environment, we constructed a mutant receptor, which differs only from the AT(1A) receptor in its reduced affinity for candesartan, a...

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PMID: 17284329
DOI: 10.1016/j.bcp.2007.01.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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