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Article

Mechanisms and functions of AT(1) angiotensin receptor internalization.

Regulatory peptides - 28 Jul 2000

Hunyady L, Catt K J, Clark A J, Gáborik Z

Abstract excerpt

The type 1 (AT(1)) angiotensin receptor, which mediates the known physiological and pharmacological actions of angiotensin II, activates numerous intracellular signaling pathways and undergoes rapid internalization upon agonist binding. Morphological and biochemical studies have shown that agonist-induced endocytosis of the AT(1) receptor occurs via clathrin-coated pits, and is dependent on two regions in the...

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PMID: 10967200
DOI: 10.1016/s0167-0115(00)00137-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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