Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of betaAPP in neuronal cells.

Journal of neurochemistry - 1 Jul 2005

Suga Kei, Saito Ayako, Tomiyama Takami, Mori Hiroshi, Akagawa Kimio

Abstract excerpt

The specific roles of syntaxin 5 (Syx 5) in the interaction with presenilin (PS) and the accumulation of beta-amyloid precursor protein (betaAPP), as well as the secretion of beta-amyloid peptide (Abeta peptide) were examined in NG108-15 cells. Syx 5, which localizes from the endoplasmic reticulum (ER) to the Golgi, bound to PS holoproteins, while the other Syxs studied did not. Among familial Alzheimer's disease...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid Precursor Protein Secretases
Share to Aspartic Acid Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Compartmentation

Share to Drug Interactions

Share to gamma-Aminobutyric Acid

Share to Neuroblastoma

Share to Peptide Biosynthesis

Share to Qa-SNARE Proteins

Source

Identifiers

PMID: 15998293
DOI: 10.1111/j.1471-4159.2005.03210.x

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of betaAPP in neuronal cells.PMID 15998293Read ↗

Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production.Semantic proximity Read ↗

Syntaxins 6 and 8 facilitate tau into secretory pathwaysSemantic proximity Read ↗

Synaptotagmins interact with APP and promote Aβ generationSemantic proximity Read ↗

The exocyst is an insulin-sensitive regulator of amyloid precursor protein trafficking and amyloid-beta generation in neuronsSemantic proximity Read ↗

Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.Semantic proximity Read ↗

Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticitySemantic proximity Read ↗

Presenilin-1 holoprotein is an interacting partner of sarco endoplasmic reticulum calcium-ATPase and confers resistance to endoplasmic reticulum stress.Semantic proximity Read ↗

X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence.Semantic proximity Read ↗

Syntaxin 5 is required for copper homeostasis in Drosophila and mammals.Semantic proximity Read ↗

Tight control of the APP-Mint1 interaction in regulating amyloid productionSemantic proximity Read ↗

Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo.Semantic proximity Read ↗

Mint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.