Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Syntaxins 6 and 8 facilitate tau into secretory pathways

26 Mar 2021

Abstract excerpt

Tau pathology initiates in defined brain regions and is known to spread along neuronal connections as symptoms progress in Alzheimer's disease (AD) and other tauopathies. This spread requires the release of tau from donor cells, but the underlying molecular mechanisms remained unknown. Here, we established the interactome of the C-terminal tail region of tau and identified syntaxin 8 (STX8) as a mediator of tau...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Cellular transport and secretion
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33769438
DOI: 10.1042/bcj20200664

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Syntaxins 6 and 8 facilitate tau into secretory pathwaysPMID 33769438Read ↗

Intracellular trafficking SNARE protein, syntaxin-6, modifies prion cellular phenotypes and risk of disease development in vivo.Semantic proximity Read ↗

Proteins Recruited to Exosomes by Tau Overexpression Implicate Novel Cellular Mechanisms Linking Tau Secretion with Alzheimer's DiseaseSemantic proximity Read ↗

Axonal Tau sorting depends on the PRR2 domain and 0N4R-specific interactions hint at distinct roles of Tau isoforms in synaptic plasticitySemantic proximity Read ↗

The Fate of Tau Aggregates Between Clearance and TransmissionSemantic proximity Read ↗

SH-SY5Y-derived neurons: A Human Neuronal Model System for Investigating TAU Sorting and Neuronal Subtype-Specific TAU VulnerabilitySemantic proximity Read ↗

Big tau: What, how, where and whySemantic proximity Read ↗

Unconventional Secretion and Intercellular Transfer of Mutant HuntingtinSemantic proximity Read ↗

Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses.Semantic proximity Read ↗

Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production.Semantic proximity Read ↗

Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway.Semantic proximity Read ↗

The Accumulation of Tau in Postsynaptic Structures: A Common Feature in Multiple Neurodegenerative Diseases?Semantic proximity Read ↗

Intercellular transmission of pathogenic proteins in ALS: Exploring the pathogenic waveSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.