Article
Syntaxin 5 is required for copper homeostasis in Drosophila and mammals.
PloS one - 20 Dec 2010
Norgate Melanie, Southon Adam, Greenough Mark, Cater Michael, Farlow Ashley, Batterham Philip, Bush Ashley I, Subramaniam V Nathan, Burke Richard, Camakaris James
Abstract excerpt
Copper is essential for aerobic life, but many aspects of its cellular uptake and distribution remain to be fully elucidated. A genome-wide screen for copper homeostasis genes in Drosophila melanogaster identified the SNARE gene Syntaxin 5 (Syx5) as playing an important role in copper regulation; flies heterozygous for a null mutation in Syx5 display increased tolerance to high dietary copper. The phenotype is...
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