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Article

Presenilin-1 holoprotein is an interacting partner of sarco endoplasmic reticulum calcium-ATPase and confers resistance to endoplasmic reticulum stress.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Jin Haifeng, Sanjo Nobuo, Uchihara Toshiki, Watabe Kazuhiko, St George-Hyslop Peter, Fraser Paul E, Mizusawa Hidehiro

Abstract excerpt

Presenilin-1 (PSEN1) is a primary component of the gamma-secretase complex, and total levels of its holoprotein and endoproteolytic fragments are tightly regulated. We examined the effects of several types of endoplasmic reticulum (ER) stress on quantitative changes in the levels of PSEN1 mRNA, h...

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Source

Identifiers

PMID: 20164584
DOI: 10.3233/JAD-2010-1360

Genes

PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20164584-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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