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Article

Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo.

Journal of neurochemistry - 1 Aug 2007

Gandy Sam, Zhang Yun-wu, Ikin Annat, Schmidt Stephen D, Bogush Alexey, Levy Efrat, Sheffield Roxanne, Nixon Ralph A, Liao Francesca-Fang, Mathews Paul M, Xu Huaxi, Ehrlich Michelle E

Abstract excerpt

Studies in continuously cultured cells have established that familial Alzheimer's disease (FAD) mutant presenilin 1 (PS1) delays exit of the amyloid precursor protein (APP) from the trans-Golgi network (TGN). Here we report the first description of PS1-regulated APP trafficking in cerebral neuron...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17630980
DOI: 10.1111/j.1471-4159.2007.04587.x

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17630980-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo.PMID 17630980Read ↗

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