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Article

Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2003

Jarvik Gail P, Hatsukami Thomas S, Carlson Chris, Richter Rebecca J, Jampsa Rachel, Brophy Victoria H, Margolin Sadie, Rieder Mark, Nickerson Deborah, Schellenberg Gerard D, Heagerty Patrick J, Furlong Clement E

Abstract excerpt

OBJECTIVE: The effects of paraoxonase (PON1) activity and of genetic variation in the PON1 promoter and coding region on carotid artery disease (CAAD) were investigated. METHODS AND RESULTS: We identified functional promoter polymorphisms and examined their effects in a cohort with and without CAAD. We used the full sequences in 23 white subjects to determine the linkage disequilibrium (LD) structure of the PON1...

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Source

Identifiers

PMID: 12805074
DOI: 10.1161/01.ATV.0000081635.96290.D3

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease.PMID 12805074Read ↗

Additional Common Polymorphisms in thePONGene Cluster Predict PON1 Activity but Not Vascular DiseaseSemantic proximity Read ↗

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The correlation of paraoxonase (PON1) activity with lipid and lipoprotein levels differs with vascular disease status.Semantic proximity Read ↗

Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype.Semantic proximity Read ↗

Variation at the paraoxonase gene locus contributes to carotid arterial wall thickness in subjects with familial hypercholesterolemia.Semantic proximity Read ↗

Paraoxonase (PON)-1: a brief overview on genetics, structure, polymorphisms and clinical relevance.Semantic proximity Read ↗

Polymorphisms in the PON gene cluster are associated with Alzheimer disease.Semantic proximity Read ↗

p.Q192R SNP of PON1 seems not to be Associated with Carotid Atherosclerosis Risk Factors in an Asymptomatic and Normolipidemic Brazilian Population Sample.Semantic proximity Read ↗

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