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Article

Genetic variations of NR1I3 and NR2B1 in Asian populations.

Drug metabolism and pharmacokinetics - 1 Jan 2013

Chew Sin Chi, Lim Joanne Siok Liu, Singh Onkar, Wong Mabel, Lee Edmund J D, Chowbay Balram

Abstract excerpt

Several nuclear receptors are being increasingly recognized for their role as master xenosensors. Among them, CAR-RXRα heterodimer, as encoded by NR1I3 and NR2B1, responds to the presence of drug compounds and regulates the transcription of a wide array of genes involved in their disposition. To investigate the frequency distribution and linkage disequilibrium patterns of NR1I3 and NR2B1 genetic variations, these...

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Identifiers

PMID: 22850739
DOI: 10.2133/dmpk.dmpk-12-sc-060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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