Regulation of CAR and PXR Expression in Health and Disease

doi:10.3390/cells9112395

Article

Regulation of CAR and PXR Expression in Health and Disease

31 Oct 2020

Abstract excerpt

Pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are members of the nuclear receptor superfamily that mainly act as ligand-activated transcription factors. Their functions have long been associated with the regulation of drug metabolism and disposition, and it is now well established that they are implicated in physiological and pathological conditions. Considerable efforts have...

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