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Article

Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation.

Molecular and cellular biology - 1 Jul 2005

Liu Juinn-Lin, Sheng Xiaoyang, Hortobagyi Zsuzsanna K, Mao Zhenyu, Gallick Gary E, Yung W K Alfred

Abstract excerpt

The tumor suppressor gene PTEN is a phosphoinositide phosphatase that is inactivated by deletion and/or mutation in diverse human tumors. Wild-type PTEN is expressed both in the cytoplasm and nucleus in normal cells, with a preferential nuclear localization in differentiated or resting cells. To elucidate the relationship between PTEN's subcellular localization and its biologic activities, we constructed...

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Source

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Identifiers

PMID: 15988030
DOI: 10.1128/MCB.25.14.6211-6224.2005
PMCID: PMC1168816

Genes

PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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