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Article

Cell cycle arrest by the PTEN tumor suppressor is target cell specific and may require protein phosphatase activity.

Experimental cell research - 1 May 2000

Hlobilkova A, Guldberg P, Thullberg M, Zeuthen J, Lukas J, Bartek J

Abstract excerpt

PTEN, a tumor suppressor commonly targeted in human cancer, possesses phosphatase activities toward both protein and lipid substrates. While PTEN suppresses gliomas through cell cycle inhibition which requires its lipid phosphatase activity, PTEN's effects on other tumor types and the role of its...

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Topics

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Share to Cell Cycle
Share to Electrophoresis, Polyacrylamide Gel
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphoprotein Phosphatases

Share to Phosphoric Monoester Hydrolases

Share to PTEN Phosphohydrolase

Share to Tumor Cells, Cultured

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Source

Identifiers

PMID: 10772829
DOI: 10.1006/excr.2000.4867

Genes

PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10772829-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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