Nuclear PTEN’s Functions in Suppressing Tumorigenesis: Implications for Rare Cancers

Abstract excerpt

) encodes a tumor-suppressive phosphatase with both lipid and protein phosphatase activity. The tumor-suppressive functions of PTEN are lost through a variety of mechanisms across a wide spectrum of human malignancies, including several rare cancers that affect pediatric and adult populations. Originally discovered and characterized as a negative regulator of the cytoplasmic, pro-oncogenic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cytokine Signaling Pathways and Interactions
• Share to PI3K/AKT/mTOR signaling in cancer
• Share to Protein Kinase Regulation and GTPase Signaling