Article
Nuclear PTEN’s Functions in Suppressing Tumorigenesis: Implications for Rare Cancers
30 Jan 2023
Abstract excerpt
) encodes a tumor-suppressive phosphatase with both lipid and protein phosphatase activity. The tumor-suppressive functions of PTEN are lost through a variety of mechanisms across a wide spectrum of human malignancies, including several rare cancers that affect pediatric and adult populations. Originally discovered and characterized as a negative regulator of the cytoplasmic, pro-oncogenic...
Topics
Join the communities discussing this publication.