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Article

A functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activity.

PloS one - 1 Jan 2015

Gil Anabel, Rodríguez-Escudero Isabel, Stumpf Miriam, Molina María, Cid Víctor J, Pulido Rafael

Abstract excerpt

Spatial regulation of the tumor suppressor PTEN is exerted through alternative plasma membrane, cytoplasmic, and nuclear subcellular locations. The N-terminal region of PTEN is important for the control of PTEN subcellular localization and function. It contains both an active nuclear localization signal (NLS) and an overlapping PIP2-binding motif (PBM) involved in plasma membrane targeting. We report a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25875300
DOI: 10.1371/journal.pone.0119287
PMCID: PMC4398541

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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