Article
The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells.
Cancer research - 15 Nov 1998
Furnari F B, Huang H J, Cavenee W K
Abstract excerpt
The PTEN gene (also called MMAC1 and TEP1) at chromosome 10q23 is mutated in a variety of predominantly late-stage tumors and has been shown to suppress glioma cell growth in vitro and in vivo. Here we sought to determine the mechanism by which PTEN mediates growth inhibition. Using the mutant PT...
Topics
- Alleles
- Apoptosis
- Cell Division
- Flow Cytometry
- G1 Phase
- Genes, Tumor Suppressor
- Genetic Vectors
- Glioma
- Humans
- PTEN Phosphohydrolase
- Phosphoric Monoester Hydrolases
- Transfection
- Tumor Cells, Cultured
- Tumor Suppressor Proteins