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Article

Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains.

Molecular and cellular biology - 1 Dec 2002

Ghioni Pamela, Bolognese Fabrizio, Duijf Pascal H G, Van Bokhoven Hans, Mantovani Roberto, Guerrini Luisa

Abstract excerpt

p63 is a transcription factor structurally related to the p53 tumor suppressor. The C-terminal region differs from p53's in that it contains a sterile alpha motif (SAM) domain and is subject to multiple alternative splicings. The N-terminal region is present in the transactivation (TA) and DeltaN configurations, with the latter lacking the transcriptional activation domain 1. Single amino acid substitutions and...

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Source

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Identifiers

PMID: 12446784
DOI: 10.1128/MCB.22.24.8659-8668.2002
PMCID: PMC139859

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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