Article
Transcriptional activity of TAp63 promoter is regulated by c-jun.
Journal of cellular physiology - 1 Nov 2010
Yao Jeng-Yuan, Pao Chia-Chu, Chen Jan-Kan
Abstract excerpt
The transcription factor p63 belongs to the p53 protein family and plays an important role in epithelial development. Recent studies showed that p63 is over-expressed in some human squamous cell carcinomas of the head and neck, suggesting a role in carcinogenesis. The p63 gene contains two promoters and alternative promoter usage generates two groups of proteins with (TAp63) or without (ΔNp63) the transactivation...
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