Article
IGF gene polymorphisms and breast cancer in African-American and Hispanic women.
International journal of oncology - 1 Jun 2011
Sarkissyan Marianna, Mishra Dhruva Kumar, Wu Yanyuan, Shang Xiying, Sarkissyan Suren, Vadgama Jaydutt V
Abstract excerpt
Previous studies from our group and others have shown that increased circulatory levels of the ligand insulin-like growth factor 1 (IGF-1) and decreased levels of the predominant IGF-1 binding protein 3 (IGFBP-3) are associated with an increased incidence of breast cancer and poor outcome. Some studies suggest that, in addition to the influence of environmental factors on the levels of IGF-1 and IGFBP-3,...
Topics
- Adult
- Black or African American
- Alleles
- Breast Neoplasms
- Female
- Genotype
- Hispanic or Latino
- Humans
- Insulin-Like Growth Factor Binding Protein 3
- Insulin-Like Growth Factor I
- Middle Aged
- Polymorphism, Genetic
- Receptor, IGF Type 1
- United States