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Article

Molecular Mechanisms of RET Activation in Human Cancer

1 Jun 2002

Abstract excerpt

Mutations that produce oncogenes with dominant gain of function target receptor protein tyrosine kinases (PTKs) in cancer and confer uncontrolled proliferation, impaired differentiation, or unrestrained survival to the cancer cell. However, insufficient PTK signaling may be responsible for developmental diseases. Gain of function of the RET receptor PTK is associated with human cancer. At the germline level,...

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Identifiers

PMID: 12095936
DOI: 10.1111/j.1749-6632.2002.tb04102.x

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